Osteoclasts what do they do

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Interferon-gamma down-regulates gene expression of cathepsin K in osteoclasts and inhibits osteoclast formation.

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Meldolesi J, Chieregatti E. Fusion has found its calcium sensor. Once differentiated, the osteoclast forms an intimate relationship with the bone surface via the alphavbeta3 integrin, which transmits matrix-derived, cytoskeleton-organizing, signals. These integrin-transmitted signals include activation of the associated proteins, c-src, syk, Vav3, and Rho GTPases. The organized cytoskeleton generates an isolated microenvironment between the cell's plasma membrane and the bone surface in which matrix mineral is mobilized by the acidic milieu and organic matrix is degraded by the lysosomal protease, cathepsin K.

This review focuses on these and other molecules that mediate osteoclast differentiation or function and thus serve as candidate anti-osteoporosis therapeutic targets. Abstract As Americans live longer, degenerative skeletal diseases, such as osteoporosis, become increasingly prevalent.